IVF clinics already offering “breast cancer-free” embryos

IVF clinics are already offering clients the possibility of sifting their embryos to ensure that they will not inherit the breast cancer genes BRCA1 and BRCA2. Belgian doctors told the European Society of Human Reproduction and Embryology (ESHRE) conference in Istanbul that preimplantation genetic diagnosis (PGD) for the genes is now feasible and established and that there have been good success rates.

PGD for the BRCA genes is highly controversial. While most PGD procedures are used to eliminate the risk of inherited sex-linked and single gene diseases (such as cystic fibrosis) in the children of affected couples, PGD for BRCA genes cannot remove the risk completely - because there is 10% background risk of breast cancer. Moreover, breast and ovarian cancers usually have a late onset. Prevention and therapeutic options constantly improving, so the chances of successful treatment and many years of healthy life are high.

Nor is breast cancer inevitable. A defective BRCA gene increases susceptibility to breast or ovarian cancer, but does not make the diseases inevitable. However, with female carriers of a mutation in either gene having a lifetime risk of 60-80% for breast cancer, and a risk of 30-60% (BRCA1) or 5-20% (BRCA2) for ovarian cancer, most doctors favour the procedure.

In Australia, two leading IVF clinics in Melbourne told the Sydney Morning Herald that 10 couples had used the test to screen embryos since 2008. “Cancer is a horrible disease… so these people want to get rid of it from their family tree,'' said Dr Lyndon Hale, medical director of Melbourne IVF. Using the test is said to double the cost of an IVF cycle from about A$3,500 to $7,000. 

This article is published by Michael Cook and BioEdge.org under a Creative Commons licence. You may republish it or translate it free of charge with attribution for non-commercial purposes following these guidelines. If you teach at a university we ask that your department make a donation. Commercial media must contact us for permission and fees. Some articles on this site are published under different terms.

comments powered by Disqus

 Search BioEdge

 Subscribe to BioEdge newsletter
rss Subscribe to BioEdge RSS feed

 Recent Posts
Controversy surrounds Canadian Medical Association’s withdrawal from world body
21 Oct 2018
Win for conscientious objection in Norway
21 Oct 2018
Stephen Hawking, transhumanist
21 Oct 2018
Queensland decriminalises abortion
21 Oct 2018
Harvard Calls for Retraction of Dozens of Studies by Noted Cardiac Researcher
20 Oct 2018

Home | About Us | Contact Us | rss RSS | Archive | Bookmark and Share | michael@bioedge.org

BioEdge - New Media Foundation Ltd © 2004 - 2009 All rights reserved -- Powered by Encyclomedia